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Distribution of Synaptic Vesicles

Jon Sporring
University of Copenhagen

April 24, 2015 at  1:15 PM
Zames MC437

Abstract: Vesicles store neurotransmitters that are released at the synapse for chemical communication between nerve cells. We have analyzed the statistical nature of synaptic vesicle’s location in serial section transmission electron microscope images of rat's brains during stress and sham-stress treatment. Serial section transmission electron microscope imaging poses a particular challenge, since the images have to be reassembled after sectioning in order to study positions in 3 dimensions, and since uncertainty on location is heavily skewed due to uncertainty about the section thickness and due the transmission process, which results in a projection. We propose methods for estimating the thickness of sections by image statistics alone and for fitting parametrized densities in the case of projection.