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Investigating the role of age-related vascular changes on brain oxygenation

Frédéric Lesage
École Polytechnique Montréal

April 24, 2015 at  11:00 AM

Abstract: Using various optical techniques: intrinsic imaging, optical coherence tomography and two photon microscopy, we investigate changes in the brain functional response with age and its relation to microvasculature. We identify brain vessel pulsatility as a contributor to flow mediated dilation and investigate the consequences of these changes on brain oxygenation. Finally, a model of the BOLD response is built from first principles to translate these results to the macroscopic world.